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    KRAS proto-oncogene, GTPase

    Background:  

    This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a

    member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating 

    mutation. The transforming protein that results is implicated in various malignancies, including lung 

    adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative 

    splicing leads to variants encoding two isoforms that differ in the C-terminal region.