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    Background:  

    This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound 

    and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins

    promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression 

    of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have

    been identified. [provided by RefSeq, Sep 2015]