2021国产福利小视频_国产AV一级A久久毛片_国产不卡免费黄视频在线互動交流_任你躁欧美一级在线精品免费_欧美午夜视频在线播放_中文在线观看国产综合_亚洲综合中字视频_国产内射精品视频_久久精品熟女亚洲_唯美清纯亚洲一区二区三区

    Background:  

    The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino

    acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from 

    one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an 

    extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning

    segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast 

    growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.      This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. 

    Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome,

    osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosoma